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Monthly Archives :

November 2024

Subclinical Herpes Simplex Virus in Neonates: What to Do?
 Subclinical Herpes Simplex Virus in Neonates: What to Do? 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Neonates can test positive for HSV without having visible lesions or other classic symptoms, leaving clinical uncertainty regarding appropriate antiviral treatment and testing protocols. Researchers at Nationwide Children’s Hospital have shared data on a sample of 17 neonates who tested positive for herpes simplex virus (HSV) at mucosal sites, without any mucosal lesions, positive blood…

Featured Researcher – Ruoning Wang, PhD
 Featured Researcher – Ruoning Wang, PhD 150 150 Alaina Doklovic
By: Alaina Doklovic

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and a professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr.…

What Is Insulin’s Role in Diabetes-Related Urinary Tract Infections?
 What Is Insulin’s Role in Diabetes-Related Urinary Tract Infections? 1024 575 Pam Georgiana
By: Pam Georgiana

Two studies reveal how impaired insulin receptors compromise immunity in people with diabetes. While excess glucose in the urine is often thought to be the main factor behind urinary tract infections in people with diabetes, two recent studies led by Laura L. Schwartz, PhD, principal investigator in the Kidney and Urinary Tract Center at Nationwide…

Selective Dorsal Rhizotomy for Cerebral Palsy: Significant Gains in Mobility and Reduction in Spasticity Treatments
 Selective Dorsal Rhizotomy for Cerebral Palsy: Significant Gains in Mobility and Reduction in Spasticity Treatments 928 1024 Erin Gregory
By: Erin Gregory

Recent research shows that selective dorsal rhizotomy (SDR) significantly boosts motor function in children with cerebral palsy (CP), particularly those who are ambulatory. The study highlights motor improvements and a reduced need for spasticity treatments, emphasizing SDR’s potential to enhance outcomes and quality of life for children with CP. Key Findings: Improvements in Motor Function…

Identifying Ancestry-Based Predictors of Survival in Black Patients with Acute Myeloid Leukemia
 Identifying Ancestry-Based Predictors of Survival in Black Patients with Acute Myeloid Leukemia 1024 768 Alaina Doklovic
By: Alaina Doklovic

Researchers use multiomic profiling to understand ancestry-specific aspects of cancer onset and outcomes. In a recent study, published in ­­­Nature Genetics, researchers from Nationwide Children’s Hospital and The Ohio State University Comprehensive Cancer Center (OSUCCC – James) compared genomic profiles of patients diagnosed with AML having self-reported and genomically-confirmed African ancestry and to patients diagnosed…

Researchers Identify Potential Prenatal Biomarkers of Congenital Heart Diseases
 Researchers Identify Potential Prenatal Biomarkers of Congenital Heart Diseases 1024 637 Katelyn Scott
By: Katelyn Scott
Heart with HLHS compared to typically developed heart

In a research letter published in Circulation Research, researchers at Nationwide Children’s describe a potential biomarker that would identify the presence of SVHD in a fetus based on a maternal blood test. Single ventricle heart diseases (SVHDs), the most severe type of congenital heart disease require immediate treatment after birth. A growing number of fetal…

Oncolytic Viroimmunotherapy Improved by Enhanced Cytokine Transgene Expression
 Oncolytic Viroimmunotherapy Improved by Enhanced Cytokine Transgene Expression 1024 575 Lauren Dembeck
By: Lauren Dembeck

Researchers were able to suppress in vivo tumor growth with an oncolytic virus by enhancing the production of the cytokine interleukin-12 in the tumors. Malignant peripheral nerve sheath tumors (MPNSTs) are rare, aggressive sarcomas that exhibit resistance to non-surgical treatment and have high rates of metastasis and relapse. The prognosis for MPNSTs is poor, with…

4 Things to Know About Bladder Exstrophy at Nationwide Children’s Hospital
 4 Things to Know About Bladder Exstrophy at Nationwide Children’s Hospital 1024 734 Abbie Miller
By: Abbie Miller

Led by V. Rama Jayanthi, MD, and Peter Cuckow, MB, BS, FRCS, the Bladder Exstrophy Program at Nationwide Children’s is poised to launch a new era of care for children in the United States. When Drs. Jayanthi and Cuckow start talking about their new program, their excitement is palpable. “We’re so excited to bring this…