BPD

Predicting Response to Bronchodilators in Infants with Bronchopulmonary Dysplasia
Predicting Response to Bronchodilators in Infants with Bronchopulmonary Dysplasia 1024 683 Mary Bates, PhD

Study emphasizes importance of identifying those patients who will respond to treatment. Certain pulmonary function test parameters in newborns with bronchopulmonary dysplasia are associated with bronchodilator response, according to a new study from researchers at Nationwide Children’s Hospital. The team also found that responders had evidence of greater dysanaptic lung growth than nonresponders. Bronchodilators are…

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Is Tracheostomy Tube Placement in Preemies Safe?
Is Tracheostomy Tube Placement in Preemies Safe? 1024 575 Mary Bates, PhD
Nurse caring for infant in Neonatal Intensive Care Unit (NICU)

The procedure is safe and effective in newborns requiring high ventilator pressures. Tracheostomy tube placement is a common procedure performed for premature infants requiring respiratory assistance. Compared to an endotracheal tube, placement of a tracheostomy tube is thought to allow the infant more opportunities for comfort, interaction, nutrition and growth. However, rates of tracheostomy tube…

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Specialized Treatment for Severe Bronchopulmonary Dysplasia Increases Survival
Specialized Treatment for Severe Bronchopulmonary Dysplasia Increases Survival 150 150 Mary Bates, PhD

Most infants with established BPD referred to Nationwide’s BPD Center improve and survive, despite the severity of their illness. In a new study, researchers analyzed the in-hospital outcomes for preterm infants with established bronchopulmonary dysplasia (BPD) referred to Nationwide Children’s Comprehensive Center for BPD. They found that despite the high degree of illness severity in…

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Bronchopulmonary Dysplasia: Characterizing the Chronic Lung Disease of Prematurity
Bronchopulmonary Dysplasia: Characterizing the Chronic Lung Disease of Prematurity 1024 575 Lauren Dembeck
Nurse caring for infant in Neonatal Intensive Care Unit (NICU)

  Precise definitions and/or classifications of bronchopulmonary dysplasia are needed to optimize outcomes. Researchers at Nationwide Children’s Hospital are continuing to help refine the definition of severe bronchopulmonary dysplasia (sBPD). In a recent study, members of the BPD Collaborative demonstrated that preterm infants with sBPD who were on invasive mechanical ventilation at 36 weeks, a…

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No Evidence Supporting Prophylactic Indomethacin Treatment for Most Preterm Infants
No Evidence Supporting Prophylactic Indomethacin Treatment for Most Preterm Infants 1024 575 Lauren Dembeck
Nurse caring for infant in Neonatal Intensive Care Unit (NICU)

Inconsistency among studies prompted researchers to take a closer look at the drug’s effects. Despite limited evidence supporting its use, prophylactic indomethacin treatment is often administered to very preterm infants within the first 24-hours after birth to reduce the risks of intraventricular hemorrhage and longer-term neonatal morbidities, such as bronchopulmonary dysplasia (BPD). Data from a…

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Timing Steroids to Maximize Lung Benefit and Avoid Brain Harm in Premature Infants
Timing Steroids to Maximize Lung Benefit and Avoid Brain Harm in Premature Infants 1024 575 Mary Bates, PhD
Nurse caring for infant in Neonatal Intensive Care Unit (NICU)

Treating infants early may decrease risk of lung disease with no added risk of neurodevelopmental impairment. Steroids are used to treat extremely premature babies with respiratory failure, yet they can be associated with delays in brain development. A recent study looked at the age of first steroid administration and the risks of lung disease and neurodevelopmental impairment…

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Prediction of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension by Combining Clinical and Genetic Data
Prediction of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension by Combining Clinical and Genetic Data 150 150 Lauren Dembeck
Best Practices in Severe BPD Treatment
Best Practices in Severe BPD Treatment 150 150 Jeb Phillips

To help standardize care, the Bronchopulmonary Dysplasia Collaborative has published a comprehensive review of evidence-based approaches for treatment of patients with severe forms of the disease. Infants with severe bronchopulmonary dysplasia (BPD) have high risks of late morbidities and mortality, but the best ways to manage these vulnerable patients are still debated. In fact, it’s…

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Stress Dose Hydrocortisone Effects on Neurodevelopment for Extremely Low Birthweight Infants
Stress Dose Hydrocortisone Effects on Neurodevelopment for Extremely Low Birthweight Infants 150 150 Abbie Roth

First placebo-controlled study on stress dose hydrocortisone and neurodevelopment shows that higher doses of hydrocortisone are not associated with brain injury or neurodevelopmental impairments, but may not be effective in reducing risk for bronchopulmonary dysplasia. Hydrocortisone is one of the 15 most frequently prescribed medications in extremely low birth weight (≤1000 g) infants in the…

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Reducing Practice Variation in Pediatrics
Reducing Practice Variation in Pediatrics 150 150 Jonathan Slaughter, MD, MPH

With variations in practice existing even between practitioners at the same institution, research can provide the keys to standardizing care and improving outcomes. Practice variation occurs when care providers diagnose or treat patients differently, even in the setting of similar disease presentation and risk factors. Variations in care have been noted at the geographic level…

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