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November 2023

Long-Term Outcomes and Quality of Life for Children Treated With Antegrade Continence Enemas
Long-Term Outcomes and Quality of Life for Children Treated With Antegrade Continence Enemas 1024 601 Pam Georgiana

ACE treatment can lead to long-term clinical and quality-of-life improvement in children with defecation disorders.   For about 10-15% of the children who experience chronic constipation or other defecation disorders, the usual behavioral modification treatments and oral medications don’t help. These disorders can significantly impact their quality of life, yet other treatment options are limited.…

What Treatment is Best for Preventing Kidney Complications in STEC Infections?
What Treatment is Best for Preventing Kidney Complications in STEC Infections? 150 150 Mary Bates, PhD

Nationwide Children’s Hospital is participating in a multicenter trial to determine the optimal way to treat children with high-risk STEC infections. Shiga toxin-producing E. coli (STEC) infections can lead to systemic disease affecting multiple organ systems, including the kidneys. Up to 20% of children infected by high-risk STEC develop hemolytic uremic syndrome (HUS), a devastating…