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Pulmonology

Shedding Light on Immune Responses in Children With Acute Asthma Exacerbations
 Shedding Light on Immune Responses in Children With Acute Asthma Exacerbations 969 533 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM
Illustration of NK Cells, T Cells, other immune cells floating across white background

The innate immune system is upregulated in children hospitalized with acute asthma exacerbations, signaling a need for therapies that target innate immune pathways to help control acute asthma flare-ups more effectively.  Asthma affects more than 6 million children in the United States, yet little is known about the immune responses that occur with acute asthma…

Is Surfactant Treatment at Birth Associated With Severe Bronchopulmonary Dysplasia?
 Is Surfactant Treatment at Birth Associated With Severe Bronchopulmonary Dysplasia? 1024 683 Pam Georgiana
By: Pam Georgiana

An observational study reviews a contemporary cohort of preterm infants. Recently, Leif D. Nelin, MD, division chief of neonatology at Nationwide Children’s and a professor of pediatrics at The Ohio State University College of Medicine, and a team of doctors in the Bronchopulmonary Dysplasia (BPD) Collaborative Registry speculated that the use of surfactant treatment in…

Evaluating Teaching Methods in Pulmonary Physiology
 Evaluating Teaching Methods in Pulmonary Physiology 1024 683 Pam Georgiana
By: Pam Georgiana

Does the flipped classroom or engaging lecture technique create better learning outcomes? In the Pediatric Pulmonary Physiology fellowship program at Nationwide Children’s, the flipped classroom approach was primarily used to teach pulmonary physiology. This necessary curriculum component can be challenging to teach and learn, particularly due to the complex nature of the subject matter and…

Higher Respiratory Severity Scores Associated with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension Risk
 Higher Respiratory Severity Scores Associated with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension Risk 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

The RSS score is noninvasive and may be clinically useful for risk stratification in extremely preterm infants. Researchers at Nationwide Children’s report that elevations in the respiratory severity score were correlated with an increased risk of bronchopulmonary dysplasia-associated pulmonary hypertension in preterm infants. This study identifies a pragmatic clinical risk score that can be measured…

Video Game-Based Therapy Makes Cardiopulmonary Rehabilitation Program More Patient-Centric
 Video Game-Based Therapy Makes Cardiopulmonary Rehabilitation Program More Patient-Centric 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES
Smiling boy outside

Patients can benefit from traditional therapeutic services as well as engaging, updated approaches to improve lung capacity and fitness.  The Cardiopulmonary Rehabilitation Program at Nationwide Children’s Hospital, launched in 2005 after a year-long pilot, has long offered services for patients to improve their ability to engage in exercise, school and activities of daily living. As…

Risk Stratification in Infants With Primary Pulmonary Vein Stenosis
 Risk Stratification in Infants With Primary Pulmonary Vein Stenosis 1024 681 Mary Bates, PhD
By: Mary Bates, PhD
sleeping infant

Categorizing infants with pulmonary vein stenosis into stable and progressive groups could help inform treatment. Primary pulmonary vein stenosis is a rare, often lethal, cardiac disease. It is challenging to treat, as the disease can be progressive in some patients but not others. In a new study, researchers from Nationwide Children’s describe outcomes among preterm infants…

Hospitals Should Use Genotyping to Monitor Bacterial Infections
 Hospitals Should Use Genotyping to Monitor Bacterial Infections 150 150 Kevin Mayhood
By: Kevin Mayhood

A team led by a pulmonologist-researcher found that in a children’s hospital, an unexpected pathogen emerges as a common cause of infection. The bacteria Acinetobacter baumannii is a widely-reported cause of healthcare-associated infections, particularly in adult intensive care units in developing countries. But a retrospective study of isolated cases at Nationwide Children’s Hospital found that Acinetobacter pittii recently emerged…

Great Minds Aren’t Thinking Alike About Asthma Care
 Great Minds Aren’t Thinking Alike About Asthma Care 150 150 Brianne Moore
By: Brianne Moore

A recent audit of the Pediatric Hospital Information System using template matching finds wide variation in care provided to pediatric asthma patients. While asthma is a common and manageable disease, nine people still die from asthma each day. It is well known that asthma is the leading cause of pediatric hospitalization as well as the…

Specialty Pharmacy for Cystic Fibrosis Improves Access to Medication
 Specialty Pharmacy for Cystic Fibrosis Improves Access to Medication 150 150 Abbie Miller
By: Abbie Miller

In a project started to increase the number of patients taking Orkambi®, access and adherence increases for all medications. The Nationwide Children’s Hospital Cystic Fibrosis (CF) Program cares for a large population of patients of all ages with cystic fibrosis.  The program has participated in many recent clinical trials, including one that led to the FDA approval…

New Drug Advances Cystic Fibrosis Care
 New Drug Advances Cystic Fibrosis Care 150 150 Kevin Mayhood
By: Kevin Mayhood

Orkambi helps reduce infections and slows loss of lung function in some patients. Matt Hennessey knew he was on the experimental medicine and not a placebo just days after he began participating in a drug trial. He felt better. The addition of Orkambi pills to his daily routine was just another part of his maintenance…

Orphan Disease Seeks Parents, Funding
 Orphan Disease Seeks Parents, Funding 1024 575 Kevin Mayhood
By: Kevin Mayhood
Color photo, family portrait of Reagan, a young girl with an orphan disease, her parents, and their dog

Research on rare pediatric diseases often remains underfunded and obscure until motivated families give scientists — and their own children — a much-needed shot at potential therapies worthy of federal funding. Reagan McGee’s pediatrician couldn’t figure out why she had cold after cold. Her parents, Karin and Peter McGee, took her to an ear, nose and…