Brain Organoids Provide Novel Mechanistic Insight into Microcephaly Associated with AUTS2 Syndrome
Brain Organoids Provide Novel Mechanistic Insight into Microcephaly Associated with AUTS2 Syndrome https://pediatricsnationwide.org/wp-content/uploads/2022/08/Hester_cerebral-organoid-pic_2-WEB.jpg 873 552 Lauren Dembeck https://pediatricsnationwide.org/wp-content/uploads/2021/03/Dembeck_headshot.gif
Researchers have functionally validated a genotype-phenotype relationship between a variant in the AUTS2 gene and neurodevelopmental deficits in AUTS2 syndrome using patient-derived brain organoids. Genetic variants in more than 100 genes, including the gene AUTS2, have been associated with autism spectrum disorders. However, the model systems used to study the mechanisms underlying how these genetic…