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Epigenetics

Transforming the Approach to Cancer Epigenomic Studies
 Transforming the Approach to Cancer Epigenomic Studies 1024 764 Abbie Miller
By: Abbie Miller

Two new publications from the Center for Childhood Cancer Research at Nationwide Children’s offer a new platform technology and proof of concept that illuminates the role of a known gene fusion driving rhabdomyosarcoma.  Synergy is an important part of scientific endeavors, and people, teams and organizations who can harness the energy of ideas and passion…

Mapping the 3D Structure of Rhabdomyosarcoma Chromatin
 Mapping the 3D Structure of Rhabdomyosarcoma Chromatin 1024 575 Abbie Miller
By: Abbie Miller
yellow squiggly lines representing chromatin strands in the nucleus

Researchers published the first comprehensive, 3D analysis of the complete rhabdomyosarcoma genome. In a paper published in Nucleic Acids Research Cancer (NAR Cancer), researchers from the Center for Childhood Cancer Research at Nationwide Children’s and their collaborators report a comprehensive 3D chromatin structural analysis and characterization of rhabdomyosarcoma (RMS). RMS is a pediatric soft-tissue tumor…