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Acute Kidney Injury

Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms
 Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms 480 320 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A new model accurately identifies neonates at risk of acute kidney injury (AKI) — and the factors physicians should address to prevent it — offering the first AKI prediction tool specific to this vulnerable population. Acute kidney injury (AKI) is common and irreversible, making preventive measures essential to maintaining health. Multiple risk prediction tools exist…

Nephrotoxic-Associated Acute Kidney Injury (NAKI) Is Avoidable
 Nephrotoxic-Associated Acute Kidney Injury (NAKI) Is Avoidable 375 280 Pam Georgiana
By: Pam Georgiana

Quality improvement initiative at Nationwide Children’s Hospital leads to significant reductions in NAKI. Nephrotoxic-associated acute kidney injury (NAKI) — an under-recognized but serious risk in pediatric hospital care — affects up to 25% of hospitalized children. It occurs when medications or toxins reduce kidney function by disrupting blood flow, damaging renal cells or triggering inflammation.…

Disrupting Mitochondrial Pyruvate Uptake in Kidney Tubular Cells Bolsters Antioxidant Responses and Protects From Acute Kidney Injury
 Disrupting Mitochondrial Pyruvate Uptake in Kidney Tubular Cells Bolsters Antioxidant Responses and Protects From Acute Kidney Injury 1024 732 Jessica Nye, PhD
By: Jessica Nye, PhD

Blocking mitochondrial pyruvate uptake in the kidney was found to upregulate oxidant defense systems, ultimately mitigating the effects of an acute kidney injury (AKI). “The kidney has these reabsorption units, tubular cells, that reabsorb glucose, amino acids and specific ions. These units spend a lot of mitochondrial energy, so they need a lot of ATP…

Acute Kidney Injury After Comprehensive Stage Two Palliation in Infants With Hypoplastic Left Heart Syndrome
 Acute Kidney Injury After Comprehensive Stage Two Palliation in Infants With Hypoplastic Left Heart Syndrome 150 150 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Infants with hypoplastic left heart syndrome who undergo the Hybrid pathway palliation commonly develop acute kidney injury after the comprehensive stage 2 procedure and may require advanced medical therapy.   In a recent Cardiology in the Young publication, Andrew Yates, MD, associate medical director for the Cardiothoracic Intensive Care Unit at Nationwide Children’s Hospital, and…