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Acute Kidney Injury

Disrupting Mitochondrial Pyruvate Uptake in Kidney Tubular Cells Bolsters Antioxidant Responses and Protects From Acute Kidney Injury
 Disrupting Mitochondrial Pyruvate Uptake in Kidney Tubular Cells Bolsters Antioxidant Responses and Protects From Acute Kidney Injury 1024 732 Jessica Nye, PhD
By: Jessica Nye, PhD

Blocking mitochondrial pyruvate uptake in the kidney was found to upregulate oxidant defense systems, ultimately mitigating the effects of an acute kidney injury (AKI). “The kidney has these reabsorption units, tubular cells, that reabsorb glucose, amino acids and specific ions. These units spend a lot of mitochondrial energy, so they need a lot of ATP…

Acute Kidney Injury After Comprehensive Stage Two Palliation in Infants With Hypoplastic Left Heart Syndrome
 Acute Kidney Injury After Comprehensive Stage Two Palliation in Infants With Hypoplastic Left Heart Syndrome 150 150 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Infants with hypoplastic left heart syndrome who undergo the Hybrid pathway palliation commonly develop acute kidney injury after the comprehensive stage 2 procedure and may require advanced medical therapy.   In a recent Cardiology in the Young publication, Andrew Yates, MD, associate medical director for the Cardiothoracic Intensive Care Unit at Nationwide Children’s Hospital, and…